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Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.
- Source :
-
Translational psychiatry [Transl Psychiatry] 2024 Sep 28; Vol. 14 (1), pp. 393. Date of Electronic Publication: 2024 Sep 28. - Publication Year :
- 2024
-
Abstract
- Low-frequency repetitive transcranial magnetic stimulation (rTMS) has emerged as an effective intervention for alleviating symptoms of psychiatric disorders, particularly schizophrenia characterized by persistent auditory verbal hallucinations (AVH). However, the underlying mechanism of its action remain elusive. This study employed a randomized controlled design to investigate the impact of low-frequency rTMS on the neural connectivity at the stimulate site, specifically left temporoparietal junction (TPJ), in schizophrenia patients with suffering from AVH. Using Dynamic Causal Modeling (DCM), this study assessed changes in directed connectivity patterns and their correlations with clinical symptomatology. The results demonstrated significant improvements in AVH. Notably, significant changes in connectivity were observed, including both abnormal functional connectivity and effective connectivity among multiple brain regions. Particularly, the inhibition effects from the left precentral gyrus and left medial superior frontal gyrus to the left TPJ were closely associated with improvements in AVH. These findings underscore the potential of rTMS to effectively modulate neural pathways implicated in hallucinations in schizophrenia, thereby providing a neurobiological foundation for its therapeutic effects.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Adult
Parietal Lobe physiopathology
Parietal Lobe diagnostic imaging
Temporal Lobe physiopathology
Temporal Lobe diagnostic imaging
Neural Pathways physiopathology
Middle Aged
Young Adult
Hallucinations therapy
Hallucinations physiopathology
Hallucinations etiology
Schizophrenia therapy
Schizophrenia physiopathology
Schizophrenia complications
Transcranial Magnetic Stimulation methods
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2158-3188
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Translational psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 39341819
- Full Text :
- https://doi.org/10.1038/s41398-024-03106-4