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Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial.

Authors :
Bersch-Ferreira ÂC
Weschenfelder C
Vieira Machado RH
Nakagawa Santos RH
Riley TM
da Silva LR
Miyada DHK
Sady ERR
de Abreu-Silva EO
Laranjeira LN
de Quadros AS
Dos Santos JL
Souza GC
Parahiba SM
Fayh APT
Bezerra DS
Carvalho APPF
Machado MMA
Vasconcelos SML
Santos MVR
de Figueiredo Neto JA
Dias LPP
Zaina Nagano FE
de Almeida CCP
Moreira ASB
de Oliveira RD
Rogero MM
Sampaio GR
da Silva Torres EAF
Weber B
Cavalcanti AB
Marcadenti A
Source :
Nutrition journal [Nutr J] 2024 Oct 01; Vol. 23 (1), pp. 118. Date of Electronic Publication: 2024 Oct 01.
Publication Year :
2024

Abstract

Background: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction.<br />Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial. Males and females over 40 years old diagnosed with previous myocardial infarction in the last 2 to 6 months were included. Patients were allocated into two groups: the Brazilian Cardioprotective diet (DICA Br) supplemented with 30 g/day of mixed nuts (10 g of peanuts; 10 g of cashew; 10 g of Brazil nuts) (intervention group, n = 193); or only DICA Br prescription (control group, n = 195). The primary outcome was low-density lipoprotein cholesterol means (in mg/dL) after 16 weeks. Secondary outcomes were other lipid biomarkers, glycemic and anthropometric data and diet quality.<br />Results: After adjustment for baseline values, participating study site, time since myocardial infarction and statin treatment regimen (high potency, moderate and low potency/no statins), no significant difference was found between the groups in low-density lipoprotein cholesterol concentrations (intervention-control difference: 3.48 mg/dL [-3.45 to 10.41], P = 0.32). Both groups improved their overall diet quality at the end of the study without differences between them after 16 weeks (intervention-control difference: 1.05 (-0.9 to 2.99); P = 0.29). Other lipids, glycemic profile and anthropometrics were also not different between study groups at the end of the study.<br />Conclusion: Adding 30 g/day of mixed nuts to the DICA Br for 16 weeks did not change lipid, glycemic and anthropometric features in the post-myocardial infarction setting.<br />Trial Registration: This study is registered on ClinicalTrials.gov website under number NCT03728127 and its World Health Organization Universal Trial Number (WHO-UTN) is U1111-1259-8105.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
1475-2891
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
Nutrition journal
Publication Type :
Academic Journal
Accession number :
39354558
Full Text :
https://doi.org/10.1186/s12937-024-01020-5