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Catestatin as a predictor for cardiac death in heart failure with mildly reduced and preserved ejection fraction.
- Source :
-
ESC heart failure [ESC Heart Fail] 2025 Feb; Vol. 12 (1), pp. 517-524. Date of Electronic Publication: 2024 Oct 03. - Publication Year :
- 2025
-
Abstract
- Aims: Endogenous catecholamine release-inhibitory peptide catestatin has been associated with heart failure (HF). This subgroup analysis of our cohort of HF compared the different effects of catestatin as a predictor for cardiac outcomes in patients with HF with reduced (HFrEF), mildly reduced (HFmrEF) or preserved (HFpEF) ejection fraction.<br />Methods: Plasma catestatin was measured in the HF patient cohort of 228 cases with a whole spectrum of ejection fraction. The cardiac deaths were analysed according to prespecified subgroups.<br />Results: Over a median follow-up of 52.5 months, the association between plasma catestatin and cardiac death was different in patients with HFrEF, HFmrEF or HFpEF [hazard ratio (HR) 1.53, 95% confidence interval (CI) 0.99-2.37 and HR 2.73, 95% CI 1.56-4.75, respectively; interaction P = 0.022]. Patients with HFmrEF/HFpEF were older and more likely to be female, with non-ischaemic cardiomyopathy and atrial fibrillation but lower levels of plasma B-type natriuretic peptide (BNP). Similar adverse cardiac events occurred in patients with HFmrEF/HFpEF as in HFrEF. Plasma catestatin was a better predictor for cardiovascular death in the HFmrEF/HFpEF patients [area under the receiver operating characteristic curve (AUC) = 0.72, 95% CI 0.45-0.74] than in the HFrEF patients (AUC = 0.59, 95% CI 0.587-0.849). The optimal cut point of plasma catestatin level of 0.86 ng/mL predicted a 2.80-fold elevated risk for cardiac death in HFmrEF/HFpEF.<br />Conclusions: Elevated plasma catestatin might be a more sensitive predictor for cardiac outcome in patients with HFmrEF/HFpEF than in HFrEF.<br /> (© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
- Subjects :
- Humans
Female
Male
Aged
Prognosis
Follow-Up Studies
Middle Aged
Ventricular Function, Left physiology
Survival Rate trends
Cause of Death trends
Heart Failure blood
Heart Failure physiopathology
Heart Failure mortality
Stroke Volume physiology
Chromogranin A blood
Peptide Fragments blood
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 2055-5822
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- ESC heart failure
- Publication Type :
- Academic Journal
- Accession number :
- 39359227
- Full Text :
- https://doi.org/10.1002/ehf2.15107