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Neutrophil-to-ferritin ratio can predict hematological causes of fever of unknown origin.
- Source :
-
Scientific reports [Sci Rep] 2024 Oct 03; Vol. 14 (1), pp. 22983. Date of Electronic Publication: 2024 Oct 03. - Publication Year :
- 2024
-
Abstract
- Despite advancements in diagnostic modalities, delineating the etiology of fever of unknown origin (FUO) remains a significant challenge for clinicians. Notably, cases with hematological malignancies often have a poor prognosis due to delayed diagnosis. This study investigated the potential of readily obtainable laboratory markers to differentiate hematological causes from other etiologies during the early stages of FUO. A retrospective analysis was conducted on the medical records of 100 patients who fulfilled the modified FUO criteria between January 2010 and April 2023. Hematological etiologies were identified in 26 of the 100 patients. Peripheral blood neutrophil, lymphocyte, platelet counts, and the systemic immune inflammation (SII) index, were significantly lower in the hematological group compared to the non-hematological group. Conversely, serum ferritin levels were demonstrably higher in the hematological group. ROC analysis identified a neutrophil-to-ferritin ratio (NFR) cutoff value of < 8.53 as optimal for predicting hematological etiology. Subsequent multivariate analysis demonstrated that the NFR was the sole independent predictor of hematological etiology (p = 0.013).This study proposes a novel approach for early diagnosis of a potentially life-threatening subset of FUO patients. The NFR presents as an inexpensive and readily available marker for predicting hematological etiology in FUO cases.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Retrospective Studies
Aged
Adult
ROC Curve
Hematologic Diseases blood
Hematologic Diseases complications
Hematologic Diseases diagnosis
Aged, 80 and over
Neutrophils
Ferritins blood
Fever of Unknown Origin blood
Fever of Unknown Origin etiology
Fever of Unknown Origin diagnosis
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39362941
- Full Text :
- https://doi.org/10.1038/s41598-024-74569-0