Increased TSPO, COX-1, and COX-2 Uptake in Bone Marrow Within a Falx Cerebri Ossification.

Abstract: Ossification is uncommon, generally asymptomatic, and often incidentally identified in imaging studies. We report on a 54-year-old man who participated as a healthy volunteer in a clinical trial using PET imaging to investigate neuroinflammation. An incidental ossified lesion in the anterior falx cerebri was revealed by MRI. CT scan showed a small hypodense center in the lesion, probably corresponding to bone marrow. The PET scans using 18 F-SF51, 11 C-PS13, and 11 C-MC1 showed increased uptake within this lesion, which was probably related to bone marrow activity within the ossification.
Competing Interests: Conflicts of interest and sources of funding: This study was funded by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health (projects ZIAMH002852 and ZIAMH002793). The authors have no potential conflicts of interest to disclose, financial, or otherwise.
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