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[Effect of a ticarcillin-clavulanic acid (timentin) combination on bacteria resistant to ticarcillin].
- Source :
-
Pathologie-biologie [Pathol Biol (Paris)] 1985 Jun; Vol. 33 (5 Pt 2), pp. 461-5. - Publication Year :
- 1985
-
Abstract
- Sixty-nine ticarcillin-resistant strains (57 Gram negative bacilli and 12 S. aureus) were tested: MICs and MBCs were determined for clavulanic acid, ticarcillin, and both agents combined using a liquid micromethod. MICs were compared to results of disk antibiotic sensitivity tests. While clavulanic acid exhibits little antibacterial activity, its action is synergistic with that of ticarcillin making 100% of Staphylococci and 84.2% of Gram negative bacilli susceptible. Among the Gram negative bacilli tested, distribution is as follows: E. coli (9/9), Klebsiella (10/14), Enterobacter (1/3), Serratia (8/8), Proteus, Providencia (8/8), Salmonella (2/2), Acinetobacter (4/4), and Pseudomonas (6/9). Although strong bacteriostatic and bactericidal activities are already achieved with 4 mg, the best results are obtained with timentin 8 mg.
- Subjects :
- Acinetobacter drug effects
Clavulanic Acid
Dose-Response Relationship, Drug
Drug Synergism
Enterobacter drug effects
Escherichia coli drug effects
Klebsiella pneumoniae drug effects
Microbial Sensitivity Tests
Penicillin Resistance
Proteus drug effects
Providencia drug effects
Pseudomonas aeruginosa drug effects
Salmonella typhimurium drug effects
Serratia drug effects
Clavulanic Acids pharmacology
Gram-Negative Bacteria drug effects
Penicillins pharmacology
Staphylococcus aureus drug effects
Ticarcillin pharmacology
Subjects
Details
- Language :
- French
- ISSN :
- 0369-8114
- Volume :
- 33
- Issue :
- 5 Pt 2
- Database :
- MEDLINE
- Journal :
- Pathologie-biologie
- Publication Type :
- Academic Journal
- Accession number :
- 3937121