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Animal and plant protein intake association with mental health, tryptophan metabolites pathways, and gut microbiota in healthy women: a cross-sectional study.
- Source :
-
BMC microbiology [BMC Microbiol] 2024 Oct 07; Vol. 24 (1), pp. 390. Date of Electronic Publication: 2024 Oct 07. - Publication Year :
- 2024
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Abstract
- Mental health is affected by tryptophane (TRP) metabolism regulation. Diet-influenced gut microbiome regulates TRP metabolism. Thus, the present study aimed to explore the relationship between type of dietary protein intake, gut microbiota, TRP metabolites homeostasis, and mental well-being in healthy women. 91 healthy females aged 18-50 were recruited based on the study protocol. Validate and reliable questionnaires assessed dietary intake and mental health. Biochemical tests and gut microbiota composition were analyzed following the manufacturer's instructions for each enzyme-linked immune sorbent assay (ELISA) kit and Real-time quantitative polymerase chain reaction (qPCR) methods respectively. Regression methods were used to estimate the considered associations. The results show that in the fully adjusted model, plant protein consumption was partially inversely associated with depression risk (OR = 0.27; 95% CI: 0.06, 1.09; P = 0.06). Higher dietary animal protein intake was marginally associated with psychological distress (OR = 2.59; 95% CI: 0.91, 7.34; P = 0.07). KYN to serotonin ratio was inversely associated with animal protein consumption (ß = 1.10; 95% CI: -0.13, 2.33; P = 0.07). Firmicutes/Bacteriodetes ratio (β = -1.27 × 103, SE = 5.99 × 102, P = 0.03) was lower in the top tertile of plant protein. A partially negative correlation was found between dietary animal protein and Prevotella abundance (β = -9.20 × 1018, SE = 5.04 × 1018, P = 0.06). Overall, significant inverse associations were found between a diet high in plant protein with mental disorders, KYN levels, and Firmicutes to Bacteroidetes ratio while adhering to higher animal protein could predispose women to psychological stress.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Adult
Cross-Sectional Studies
Middle Aged
Young Adult
Adolescent
Depression microbiology
Depression metabolism
Diet
Plant Proteins metabolism
Animal Proteins, Dietary
Bacteria classification
Bacteria genetics
Bacteria isolation & purification
Bacteria metabolism
Animals
Healthy Volunteers
Gastrointestinal Microbiome
Tryptophan metabolism
Mental Health
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2180
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 39375584
- Full Text :
- https://doi.org/10.1186/s12866-024-03534-8