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Inpatient zoledronic acid in older hip fracture patients is well tolerated and safe.
- Source :
-
Archives of osteoporosis [Arch Osteoporos] 2024 Oct 10; Vol. 19 (1), pp. 96. Date of Electronic Publication: 2024 Oct 10. - Publication Year :
- 2024
-
Abstract
- Administering zoledronic acid (ZA) to older hip fracture patients during the hospital stay has faced safety concerns. However, in this study of 161 patients, no ZA-related side effects or readmissions were observed, demonstrating that ZA administration during hospitalization is safe and effective for secondary fracture prevention.<br />Purpose: According to the 2022 Dutch 'Osteoporosis and fracture prevention' guideline, zoledronic acid (ZA) is the preferred osteoporosis treatment for hip fracture patients. Less than 25% of hip fracture patients visit the outpatient fracture liaison service, therefore inpatient administration of ZA during the hip fracture hospitalization is now recommended in patients > 75 years. In the OLVG Hospital, inpatient administration of ZA during hospitalization for hip fracture in older patients has been standard of care since 2020.<br />Methods: This single center retrospective observational follow-up study included hip fracture patients > 75 years admitted to the orthogeriatric ward of the OLVG Hospital, and treated with 5 mg of ZA intravenously on the day of hospital discharge between June 2020 and December 2022. Life expectancy estimated < 12 months, creatinine clearance < 35 ml/min, hypocalcemia, and high risk of osteonecrosis of the jaw were contra-indications. During three months of follow-up (FU) adverse events, emergency room visits, hospital readmissions, and death were recorded.<br />Results: In 161 consecutive hospitalized hip fracture patients (mean age 86 ± 6 years, 65% female, 18% nursing home) ZA was administered and no adverse events were recorded. During 3 months of FU, 8 patients (5%) visited the emergency room, 19 patients (12%) were re-admitted to the hospital, 3 with a new fracture (2 contralateral hip, 1 radius), and 17 patients (11%) died of reasons unrelated to ZA.<br />Conclusion: This study shows that inpatient administration of zoledronic acid during hip fracture hospitalization is safe and feasible to prevent future fragility fractures in older hip fracture patients.<br /> (© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
- Subjects :
- Humans
Female
Male
Aged
Aged, 80 and over
Retrospective Studies
Follow-Up Studies
Osteoporosis drug therapy
Osteoporotic Fractures prevention & control
Zoledronic Acid administration & dosage
Zoledronic Acid therapeutic use
Zoledronic Acid adverse effects
Hip Fractures
Bone Density Conservation Agents administration & dosage
Bone Density Conservation Agents adverse effects
Bone Density Conservation Agents therapeutic use
Hospitalization statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1862-3514
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of osteoporosis
- Publication Type :
- Academic Journal
- Accession number :
- 39388042
- Full Text :
- https://doi.org/10.1007/s11657-024-01453-9