p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury.

Authors :: Kar P
Sivasailam A
Lavarti R
Cai L
Thangaraju M
Nguyen E
Mundluru B
Raju RP
Source :: Npj aging [NPJ Aging] 2024 Oct 14; Vol. 10 (1), pp. 45. Date of Electronic Publication: 2024 Oct 14.
Publication Year :: 2024
Abstract: The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.<br /> (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)