Back to Search Start Over

New Challenges: Use and Interpretation of Radius Bone Mineral Density.

Authors :
Cauley JA
Lui LY
LeBoff MS
Watts NB
Source :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Context: It is unknown if isolated low bone mineral density (BMD) "osteoporosis" at the radius is associated with increased fracture risk, not only at the wrist but elsewhere and whether it reflects more generalized skeletal fragility.<br />Objective: To review the association of radius BMD and fracture risk, the epidemiology of wrist fractures, isolated osteoporosis at the radius and the concordance between radial BMD and femoral neck BMD.<br />Methods: We completed a narrative literature review on radius BMD and fracture risk and current recommendations for measurement of radial BMD. We updated results of radial BMD and fracture results from the Study of Osteoporotic Fractures over 20 years and examined the concordance of BMD at the distal and proximal radius with femoral neck BMD T -scores.<br />Results: Radius BMD is a robust predictor of all types of fractures including hip and wrist but there is insufficient evidence to suggest that radius BMD predicts wrist fractures better than fractures at other sites. Fractures of the wrist tend to occur in younger, healthier women compared with hip and spine fractures. Nevertheless, wrist fractures are associated with an increased risk of future fractures and represent a missed opportunity for intervention. On a population level, the discordance between radius BMD and femoral neck BMD is small. But women with isolated osteoporosis at the radius had biochemical and microarchitecture deterioration that were similar to women with hip osteoporosis.<br />Conclusion: Future research should address the clinical implications of isolated osteoporosis at the radius and whether treatment is warranted.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our siteā€”for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.)

Details

Language :
English
ISSN :
1945-7197
Database :
MEDLINE
Journal :
The Journal of clinical endocrinology and metabolism
Publication Type :
Academic Journal
Accession number :
39403961
Full Text :
https://doi.org/10.1210/clinem/dgae726