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Genomic Biomarkers Predict Response to Combined ATR Inhibition and Radiotherapy.

Genomic Biomarkers Predict Response to Combined ATR Inhibition and Radiotherapy.

Authors :
Schrank BR
Colbert LE
Source :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Dec 16; Vol. 30 (24), pp. 5505-5507.
Publication Year :
2024

Abstract

For decades, chemoradiosensitization with checkpoint kinase inhibitors has been proposed but largely unexplored. A recent study reports that the novel ataxia telangiectasia and Rad3-related kinase inhibitor RP-3500 synergizes with radiation to control Atm-/- tumors in vivo. RP-3500 did not radiosensitize wild-type or Brca-1-deficient tumors, highlighting the need for a genotype-tailored approach. See related article by Ng et al., p. 5643.<br /> (©2024 American Association for Cancer Research.)

Details

Language :
English
ISSN :
1557-3265
Volume :
30
Issue :
24
Database :
MEDLINE
Journal :
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Type :
Academic Journal
Accession number :
39422899
Full Text :
https://doi.org/10.1158/1078-0432.CCR-24-2306