Role of TRIP13 in human cancer development.

Authors :: Chen C
Li P
Fan G
Yang E
Jing S
Shi Y
Gong Y
Zhang L
Wang Z
Source :: Molecular biology reports [Mol Biol Rep] 2024 Oct 22; Vol. 51 (1), pp. 1088. Date of Electronic Publication: 2024 Oct 22.
Publication Year :: 2024
Abstract: As an AAA + ATPase, thyroid hormone receptor interacting protein 13 (TRIP13) primarily functions in DNA double-strand break repair, chromosome recombination, and cell cycle checkpoint regulation; aberrant expression of TRIP13 can result in chromosomal instability (CIN). According to recent research, TRIP13 is aberrantly expressed in a variety of cancers, and a patient's poor prognosis and tumor stage are strongly correlated with high expression of TRIP13. Tumor cell and subcutaneous xenograft growth can be markedly inhibited by TRIP13 knockdown or TRIP13 inhibitor administration. In the initiation and advancement of human malignancies, TRIP13 seems to function as an oncogene. Based on available data, TRIP13 may function as a biological target and biomarker for cancer. The creation of inhibitors that specifically target TRIP13 may present novel approaches to treating cancer.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)