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Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis.

Authors :
Littlejohn R
Zambrano-Carrasco J
Zou J
Yao Y
Kim IM
Zhou J
Li J
Su H
Source :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Dec; Vol. 197, pp. 40-44. Date of Electronic Publication: 2024 Oct 20.
Publication Year :
2024

Abstract

Heart development is a complex spatiotemporal process involving a series of orchestrated morphogenic events that result in the formation of an efficient pumping organ. How posttranslational mechanisms regulate heart development remains poorly understood. Therefore, we investigate how neddylation, the attachment of NEDD8 to target proteins, coordinates cardiogenesis. Abrogation of neddylation by deleting Nae1 in the heart via Sm22α <superscript>Cre</superscript> led to early embryonic lethality. Mutant hearts exhibited deficits in trabeculation and expansion of the compact layer due to reduced cardiomyocyte proliferation, which was linked to abnormal Notch signaling in the developing heart. Overall, our findings demonstrate an essential role for neddylation in cardiogenesis.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2024. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
1095-8584
Volume :
197
Database :
MEDLINE
Journal :
Journal of molecular and cellular cardiology
Publication Type :
Academic Journal
Accession number :
39437885
Full Text :
https://doi.org/10.1016/j.yjmcc.2024.10.006