Physivitrins I-R, lanostane triterpenoids with anti-inflammatory activities from the fungus Physisporinus vitreus.

Chemical investigation on the rice fermentation of the fungus Physisporinus vitreus led to the isolation of ten previously undescribed lanostane triterpenoids, physivitrins I-R, and three known analogues. The new structures were elucidated on the basis of extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS, UV and ECD. Physivitrins I and P exhibited significant inhibitory activities against NO production in LPS-activated RAW267.4 macrophages with IC ₅₀ values of 8.2 and 11.5 μM, respectively. The comprehensive data indicated that P. vitreus is rich in lanostane triterpenes and has potential anti-inflammatory application prospects.
Competing Interests: Declaration of competing interest The corresponding authors, on behalf of all authors of the manuscript, disclose that there is no potential competing or non-financial interest.
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