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Organization of choline acetyltransferase-containing structures in the forebrain of the rat.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 1986 Jan; Vol. 6 (1), pp. 281-92. - Publication Year :
- 1986
-
Abstract
- The cholinergic structures in the forebrain of the rat were studied immunohistochemically with a monoclonal antibody to choline acetyltransferase (ChAT) which has proven to be particularly suited to reveal the trajectory of ChAT-positive fibers and their terminations. The habenulo-interpeduncular tract contained the most distinctly ChAT-positive fibers. Here, ChAT-positivity was demonstrated in the perikarya, fibers and terminal field. From the basal forebrain, ChAT-positive fiber bundles could be followed rostrally to the olfactory bulb, dorsomedially to the neocortex and hippocampus, and dorsocaudally to the hippocampus. Terminations of ChAT-positive fibers in these regions were either boutons terminaux (in the interpeduncular nucleus), finely granular (in the hippocampus) or a network of varicose fibers (in the olfactory bulb and neocortex). Cholinergic terminal fields were also demonstrated in the following regions: the nucleus of the lateral olfactory tract, the olfactory tubercle, the pyriform cortex, the lateral nucleus and part of the basal nucleus of the amygdala, the caudate-putamen, the nucleus accumbens, some thalamic nuclei, and the suprachiasmatic nucleus of the hypothalamus. In most of these regions, ChAT-positivity appeared as either fine granules or a meshwork of varicose fibers.
- Subjects :
- Amygdala enzymology
Animals
Antibodies, Monoclonal
Caudate Nucleus enzymology
Globus Pallidus enzymology
Hippocampus enzymology
Histocytochemistry
Hypothalamus enzymology
Nerve Fibers enzymology
Nucleus Accumbens enzymology
Olfactory Bulb enzymology
Putamen enzymology
Rats
Rats, Inbred Strains
Thalamus enzymology
Tissue Distribution
Brain enzymology
Choline O-Acetyltransferase analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0270-6474
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 3944622