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Lifespan of male and female APP/PS1 and APP NL-F/NL-F mouse models of Alzheimer's disease.

Lifespan of male and female APP/PS1 and APP NL-F/NL-F mouse models of Alzheimer's disease.

Authors :
Roberts H
Fang Y
Quinn K
Hill T
Peck MR
Bartke A
Hascup KN
Hascup ER
Source :
BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
Publication Year :
2024

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP <superscript>NL-F/NL-F</superscript> ) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP <superscript>NL-F/NL-F</superscript> mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.<br />Competing Interests: CONFLICT OF INTEREST/ DISCLOSURE STATEMENT The authors have no conflict of interest to report.

Details

Language :
English
ISSN :
2692-8205
Database :
MEDLINE
Journal :
BioRxiv : the preprint server for biology
Publication Type :
Academic Journal
Accession number :
39464050
Full Text :
https://doi.org/10.1101/2024.10.15.618508