A Randomized, Comparative Study of Skin Adhesion Between CATHEREEPLUS Pad and Tegaderm Pad Film Dressings in Healthy Participants.

Objective This study aimed to compare the adhesion of CATHEREEPLUS _TM Pad (CPSP; NICHIBAN Co., Ltd., Tokyo, Japan) and Tegaderm ^TM +Pad (TGMP; 3M, Maplewood, MN, USA) film dressings on the forearm skin of healthy participants over a four-day application period. Methods Twenty-six randomly assigned participants received CPSP dressing on one arm and TGMP on the other. The primary endpoint was adhesion to the skin after four days of dermal application. Secondary endpoints were adhesion and itchiness during the application period, pain experienced during dressing removal, skin maceration, adhesive residue immediately post-dressing removal, and skin reactions at one and 24 hours post-dressing removal. All endpoints were evaluated using a five- or six-point scoring system. Results Following four days of dressing application, 77% of participants in the CPSP group and 73% of those in the TGMP group scored 4 (most) or 5 (complete) for adhesion. No clinically significant problems such as itchiness, pain, skin maceration, adhesive residue, or skin reactions were observed in either group. No statistically significant differences in any of the endpoints were observed between the two groups. Conclusion Both CPSP and TGMP dressings showed good adhesion to the skin during four days of dermal application in healthy participants, with no significant difference in adhesion observed between the two groups.
Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Shiba Palace Clinic issued approval 152395-35242. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: This study was funded by NICHIBAN Co., Ltd., the manufacturer of CATHEREEPLUS PAD. SS, YK, EN, and TK are employees of NICHIBAN Co., Ltd. The honesty of the study was not traded for any monetary benefit. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
(Copyright © 2024, Sakurai et al.)