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Impaired response of pancreatic polypeptide to hypoglycaemia: an early sign of autonomic neuropathy in diabetics.

Impaired response of pancreatic polypeptide to hypoglycaemia: an early sign of autonomic neuropathy in diabetics.

Authors :
Krarup T
Schwartz TW
Hilsted J
Madsbad S
Verlaege O
Sestoft L
Source :
British medical journal [Br Med J] 1979 Dec 15; Vol. 2 (6204), pp. 1544-6.
Publication Year :
1979

Abstract

The pancreatic polypeptide (PP) response to insulin-induced hypoglycaemia was studied in 18 juvenile diabetics and was calculated as the difference between the prestimulatory PP concentration and the maximal concentration measured. The response was severely impaired in patients with autonomic neuropathy (mean +/- SE of mean 22 +/- 12 pmol/l) as compared with patients without neuropathy (252 +/- 51 pmol/l). Patients whose diabetes was of only a few years' duration showed a normal PP response to hypoglycaemia, and the response diminished significantly with increasing duration of diabetes. The decreased PP response to hypoglycaemia was significantly correlated with an increased threshold of the sense of vibration, (rs = 0.86). These results suggest that impaired, secretion of PP may serve as an early sign of autonomic neuropathy in diabetes.

Details

Language :
English
ISSN :
0007-1447
Volume :
2
Issue :
6204
Database :
MEDLINE
Journal :
British medical journal
Publication Type :
Academic Journal
Accession number :
394798
Full Text :
https://doi.org/10.1136/bmj.2.6204.1544