History, Advances, and Challenges of Sickle Cell Disease Treatment.

Sickle cell disease (SCD) is marked by red blood cells that deform into a sickle shape, causing severe health complications. Historic neglect and slow therapeutic progress have left many, especially African descendants, vulnerable. Recent treatment strides include novel drugs and gene therapy, promising improved management. Nonetheless, challenges persist with treatment adoption because of cost, adverse effects, and accessibility. Advancements hold hope for enhanced life quality and longevity for SCD patients.
Competing Interests: Disclosure Dr R. Walia and Dr D.E. Sabath do not have any financial disclosures. Dr K.Y. Fertrin has received research support (Agios Pharmaceuticals, United States), consultancy fees (Sanofi Genzyme, Agios Pharmaceuticals), and speaker fees (Agios Pharmaceuticals).
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