Nitro-fatty acids: promising agents for the development of new cancer therapeutics.

Nitro-fatty acids (NO ₂ -FAs) are endogenous pleiotropic lipid mediators regarded as promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two decades, the anti-inflammatory and cytoprotective actions of NO ₂ -FAs and several molecular targets have been identified. More recently, preclinical studies have demonstrated their potential as prospective cancer therapeutics with favorable safety and tumor-selective profiles. In this review, we describe the mechanisms of action, with a focus on NO ₂ -FA antineoplastic and chemosensitizing effects. We also address the potential therapeutic applications of endogenous and structurally modified NO ₂ -FAs species in cancer treatment.
Competing Interests: Declaration of interests F.J.S. and C.A.N. acknowledge financial interests in Creegh Pharmaceuticals Inc. F.J.S. has a financial interest in Furanica, Inc. The authors have no other conflicts of interest to declare. All descriptions, interpretations, and opinions expressed in the manuscript are solely those of the contributing authors and do not necessarily represent the views (s) of the affiliated institutions, organizations, or funding bodies.
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