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Revolutionizing medicine: Recent developments and future prospects in stem-cell therapy.

Authors :
Hussen BM
Taheri M
Yashooa RK
Abdullah GH
Abdullah SR
Kheder RK
Mustafa SA
Source :
International journal of surgery (London, England) [Int J Surg] 2024 Nov 05. Date of Electronic Publication: 2024 Nov 05.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. This review examines the revolutionary frontier of treatments utilizing stem cells, highlighting the distinctive abilities of stem cells to undergo regeneration and specialized cell differentiation into a wide variety of phenotypes. This paper aims to guide researchers, physicians, and stakeholders through the intricate terrain of stem-cell therapy, examining the processes, applications, and challenges inherent in utilizing stem cells across diverse medical disciplines. The historical journey from foundational contributions in the late 19th and early 20th centuries to recent breakthroughs, including ESC isolation and iPSC discovery, has set the stage for monumental leaps in medical science. Stem cells' regenerative potential spans embryonic, adult, induced pluripotent, and perinatal stages, offering unprecedented therapeutic opportunities in cancer, neurodegenerative disorders, cardiovascular ailments, spinal cord injuries, diabetes, and tissue damage. However, difficulties, such as immunological rejection, tumorigenesis, and precise manipulation of stem-cell behavior, necessitate comprehensive exploration and innovative solutions. This manuscript summarizes recent biotechnological advancements, critical trial evaluations, and emerging technologies, providing a nuanced understanding of the triumphs, difficulties, and future trajectories in stem cell-based regenerative medicine. Future directions, including precision medicine integration, immune modulation strategies, advancements in gene-editing technologies, and bioengineering synergy, offer a roadmap in stem cell treatment. The focus on stem-cell therapy's potential highlights its significant influence on contemporary medicine and points to a future in which individualized regenerative therapies will alleviate various medical disorders.<br /> (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Details

Language :
English
ISSN :
1743-9159
Database :
MEDLINE
Journal :
International journal of surgery (London, England)
Publication Type :
Academic Journal
Accession number :
39497543
Full Text :
https://doi.org/10.1097/JS9.0000000000002109