The Effect of Time-Restricted Eating on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.

Background/Objectives: Endogenous metabolic pathways periodically adjust with fluctuations in day and night, a biological process known as circadian rhythm. Time-restricted eating (TRE) aligns the time of food intake with the circadian rhythm. This study aims to investigate the effects of TRE on body weight, body composition and cardiometabolic risk factors. Methods: We reviewed articles from PubMed and Cochrane libraries for clinical trials that compare TRE with regular diet without calorie restriction. We conducted a meta-analysis of 26 studies. Results: Participants who followed TRE demonstrated reduction in body weight [mean-MD: -1.622 kg, (95% confidence interval (CI -2.302 to -0.941)], body mass index (BMI) [MD: -0.919 kg/m ² (95% CI: -1.189 to -0.650)], waist circumference [MD: -2.015 cm (95% CI: -3.212 to -0.819] and whole-body fat mass (WBFM) [MD: -0.662 kg (95% CI: -0.795 to -0.530)]. Improvements in cardiometabolic risk factors such as a decrease in insulin concentrations [MD: -0.458 mIU/L, (95% CI: -0.843 to -0.073)], total cholesterol [MD: -2.889 mg/dL (95% CI: -5.447 to -0.330) and LDL concentrations [MD: -2.717 mg/dL (95% CI: -4.412 to -1.021)] were observed. Conclusions: TRE is beneficial for weight loss and improvements in cardiometabolic risk factors. Further large-scale clinical trials are needed to confirm these findings.