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BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis.
- Source :
-
Frontiers in immunology [Front Immunol] 2024 Oct 28; Vol. 15, pp. 1405013. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Introduction: The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients.<br />Materials and Methods: In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages.<br />Results: Expanded T cell receptor (TCR) clones were predominantly SARS-CoV-2-specific, but represented only a small fraction of the total repertoire in all patients. In contrast, while deceased patients exhibited monoclonal B cell receptor (BCR) expansions without COVID-19 specificity, survivors demonstrated diverse and specific BCR clones. These findings suggest that neither TCR diversity nor BCR monoclonal expansions are sufficient for viral clearance and subsequent recovery. Differential gene expression analysis revealed that protein biosynthetic processes were enriched in survivors, but that potentially damaging mitochondrial ATP metabolism was activated in the deceased.<br />Conclusion: This study underscores that BCR repertoire diversity, but not TCR diversity, correlates with favorable outcomes in COVID-19.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Paran, Oyama, Khasawneh, Ai, Ismanto, Sherif, Saputri, Ono, Saita, Takei, Horiuchi, Yagi, Matsuura, Okazaki, Takahashi, Standley, Tabe and Naito.)
- Subjects :
- Humans
Prognosis
Male
Female
Middle Aged
Aged
Single-Cell Analysis
Adult
B-Lymphocytes immunology
COVID-19 immunology
Receptors, Antigen, B-Cell genetics
Receptors, Antigen, B-Cell metabolism
Receptors, Antigen, B-Cell immunology
Receptors, Antigen, T-Cell genetics
Receptors, Antigen, T-Cell immunology
Receptors, Antigen, T-Cell metabolism
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39530088
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1405013