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Phytochemical characterization and comparative analysis of cycloartane-type triterpenes in Astragalus adsurgens and Astragalus membranaceus.
- Source :
-
Planta medica [Planta Med] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A‒D (1‒4) and 3-methyl-3,4-seco-cyclostellanol (5), together with two known analogues cycloastragenol (6) and cyclopycanthogenin (7), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1439-0221
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 39587009
- Full Text :
- https://doi.org/10.1055/a-2486-8873