Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis.

Authors :: Jove A
Lin C
Hwang JH
Balasubramanian V
Fernandez-Becker NQ
Huang RJ
Source :: The American journal of gastroenterology [Am J Gastroenterol] 2024 Nov 26. Date of Electronic Publication: 2024 Nov 26.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Introduction: Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk.<br />Methods: We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET.<br />Results: We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET.<br />Discussion: Gastrin levels differ significantly between patients with AMAG with and without gNET.<br /> (Copyright © 2024 by The American College of Gastroenterology.)

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