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[Distribution of iodinated antibodies to the human organ-specific intestinal antigen in athymic mice with heterotransplanted tumors].

Authors :
Aleksander SK
Pugachev KK
Revazova ES
Fidler LM
Avdeev GI
Source :
Meditsinskaia radiologiia [Med Radiol (Mosk)] 1986 Apr; Vol. 31 (4), pp. 26-9.
Publication Year :
1986

Abstract

131I labeled rabbit antibodies to the human epithelial intestinal antigen beta 1-MA was administered intravenously to nude mice together with human tumor grafts: colon cancer (CC), breast cancer, Ewing's sarcoma and hepatoma. Antibodies to beta 1-MA were selectively accumulated in CC only, excluding the other tumors. Iodinated nonspecific rabbit IgG in mice with CC were distributed like antibodies to beta 1-MA in the body of mice with control heterografts. A conclusion was made of the promising use of labeled antibodies to beta 1-MA in radioimmuno-scintigraphy of CC and its metastases.

Details

Language :
Russian
ISSN :
0025-8334
Volume :
31
Issue :
4
Database :
MEDLINE
Journal :
Meditsinskaia radiologiia
Publication Type :
Academic Journal
Accession number :
3959807