Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?

Authors :: Martin PJP
Willicombe M
Roufosse C
Source :: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2024 Nov 13; Vol. 37, pp. 13280. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).
Publication Year :: 2024
Abstract: Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and refinement of recommendations for histocompatibility testing by the Sensitization in Transplantation Assessment of Risk (STAR) workgroup. This mini-review discusses the latest understanding of pathophysiological mechanisms, clinical evidence for the pathogenicity of AT1R-Ab, and methods of laboratory testing.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Martin, Willicombe and Roufosse.)

Subjects :: Humans
Kidney Transplantation adverse effects
Histocompatibility Testing methods
Receptor, Angiotensin, Type 1 immunology
Graft Rejection immunology
Organ Transplantation

Language :: English
ISSN :: 1432-2277
Volume :: 37
Database :: MEDLINE
Journal :: Transplant international : official journal of the European Society for Organ Transplantation
Publication Type :: Academic Journal
Accession number :: 39606688
Full Text :: https://doi.org/10.3389/ti.2024.13280

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