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Co-occurrence of Loeys-Dietz syndrome with postural orthostatic tachycardia syndrome: A case series.

Co-occurrence of Loeys-Dietz syndrome with postural orthostatic tachycardia syndrome: A case series.

Authors :
Boustany M
Arvantaj A
Chémali KR
Source :
Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Dec; Vol. 256, pp. 103220. Date of Electronic Publication: 2024 Nov 20.
Publication Year :
2024

Abstract

Loeys-Dietz syndrome (LDS) is a connective tissue disorder arising from mutations in the TGF- β signaling pathway. The spectrum of clinical manifestations is broad, and includes vascular, skeletal, and craniofacial abnormalities, along with joint hypermobility. No evidence of postural orthostatic tachycardia syndrome (POTS) in these patients has been reported. We report here a case series of patients with LDS presenting to the autonomic clinic and found to have POTS. Understanding the exact pathophysiology of this association requires further studies. Acknowledging the co-occurrence of these conditions is important to improve outcomes, and managing POTS in LDS patients necessitates an interdisciplinary approach.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7484
Volume :
256
Database :
MEDLINE
Journal :
Autonomic neuroscience : basic & clinical
Publication Type :
Academic Journal
Accession number :
39612734
Full Text :
https://doi.org/10.1016/j.autneu.2024.103220