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Co-occurrence of Loeys-Dietz syndrome with postural orthostatic tachycardia syndrome: A case series.
Co-occurrence of Loeys-Dietz syndrome with postural orthostatic tachycardia syndrome: A case series.
- Source :
-
Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Dec; Vol. 256, pp. 103220. Date of Electronic Publication: 2024 Nov 20. - Publication Year :
- 2024
-
Abstract
- Loeys-Dietz syndrome (LDS) is a connective tissue disorder arising from mutations in the TGF- β signaling pathway. The spectrum of clinical manifestations is broad, and includes vascular, skeletal, and craniofacial abnormalities, along with joint hypermobility. No evidence of postural orthostatic tachycardia syndrome (POTS) in these patients has been reported. We report here a case series of patients with LDS presenting to the autonomic clinic and found to have POTS. Understanding the exact pathophysiology of this association requires further studies. Acknowledging the co-occurrence of these conditions is important to improve outcomes, and managing POTS in LDS patients necessitates an interdisciplinary approach.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Loeys-Dietz Syndrome complications
Loeys-Dietz Syndrome genetics
Loeys-Dietz Syndrome physiopathology
Postural Orthostatic Tachycardia Syndrome physiopathology
Postural Orthostatic Tachycardia Syndrome complications
Postural Orthostatic Tachycardia Syndrome therapy
Postural Orthostatic Tachycardia Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7484
- Volume :
- 256
- Database :
- MEDLINE
- Journal :
- Autonomic neuroscience : basic & clinical
- Publication Type :
- Academic Journal
- Accession number :
- 39612734
- Full Text :
- https://doi.org/10.1016/j.autneu.2024.103220