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[Precancerous and cancerous lesions of the esophagus and forestomach in mice with skin exposure to a heavy catalytic gas oil].
- Source :
-
Voprosy onkologii [Vopr Onkol] 1986; Vol. 32 (2), pp. 56-61. - Publication Year :
- 1986
-
Abstract
- Painting with heavy catalytic gas oil was followed by skin tumor development in 97 (84.3%) mice: benign lesions--21 and carcinoma--76 cases. Pathologic changes in the upper part of the digestive tract were found in 55 out of 106 mice (51.9%): precancerous lesions (leukoplakia, dysplasia and papilloma) in 54 cases and cancer in one animal. Frequency of development of papilloma in the cardia was 27 times that in the esophagus. Multicentric growth was typical of precancerous lesions. Papilloma of the cardia was found in one control animal. Resorptive as well as direct action of gas oil seem to have been the causative factors of the development of precancerous and neoplastic lesions of the upper part of the gastrointestinal tract. The agent found its way into the digestive tract as animals licked each other in the course of the experiments.
- Subjects :
- Administration, Topical
Animals
Cardia drug effects
Cardia pathology
Esophageal Neoplasms pathology
Esophagus drug effects
Esophagus pathology
Female
Leukoplakia chemically induced
Leukoplakia pathology
Mice
Papilloma chemically induced
Papilloma pathology
Precancerous Conditions pathology
Stomach Neoplasms pathology
Time Factors
Esophageal Neoplasms chemically induced
Petroleum toxicity
Precancerous Conditions chemically induced
Skin Absorption drug effects
Stomach Neoplasms chemically induced
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-3758
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Voprosy onkologii
- Publication Type :
- Academic Journal
- Accession number :
- 3962244