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Combined quantitative analysis of the nigro-striata system in multiple system atrophy and Parkinson's disease.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2024 Nov 26; Vol. 468, pp. 123331. Date of Electronic Publication: 2024 Nov 26. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Degeneration of the nigrostriatal system occurs in multiple system atrophy (MSA) and Parkinson's disease (PD) via distinct pathological mechanisms. Here, we investigated nigrostriatal degeneration in MSA and PD by combining a newly developed method for evaluating the regional accumulation of dopamine transporter single-photon emission computed tomography (DAT SPECT) and individual voxel-based morphometry adjusting covariates (iVAC). We recruited 17 MSA patients and 13 PD patients, and compared their clinical and imaging indices. All patients underwent DAT SPECT and head three-dimensional T1-weighted magnetic resonance imaging. We calculated the specific binding ratio (SBR) of the putamen and caudate separately using a region-based method, and evaluated the association between the SBR and iVAC Z-score. SBR values of the putamen and caudate were lower in the PD group than in the MSA group (p < 0.001 for both). The MSA and PD groups had lower SBR values in the putamen than in the caudate (p < 0.05 and p < 0.001, respectively). We found a negative correlation between the putamen SBR and iVAC Z-score in MSA (p < 0.001, r = -0.775), but such a correlation was not detected in PD. For the caudate, there was no correlation between the SBR and iVAC Z-score in MSA and PD. Our results indicate different mechanisms of reduced uptake of DATs in MSA and PD. The association between the striatal SBR and iVAC Z-score suggests parallel degeneration in the substantia nigra and striatum in MSA.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-5883
- Volume :
- 468
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 39631218
- Full Text :
- https://doi.org/10.1016/j.jns.2024.123331