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Contemporary Insights into LMNA Cardiomyopathy.
- Source :
-
Current cardiology reports [Curr Cardiol Rep] 2025 Jan 27; Vol. 27 (1), pp. 40. Date of Electronic Publication: 2025 Jan 27. - Publication Year :
- 2025
-
Abstract
- Purpose of Review: This review aims to explore how a diagnosis of LMNA-related cardiomyopathy (LMNA-CM) informs clinical management, focusing on the prevention and management of its complications, through practical clinical strategies.<br />Recent Findings: Longitudinal studies have enhanced our understanding of the natural history of LMNA-CM including its arrhythmic and non-arrhythmic complications. A LMNA specific ventricular arrhythmia risk prediction strategy has been integrated into clinical practice guidelines. Although less robust, observational studies are shaping gene-specific strategies for mitigating other complications including atrioventricular block, atrial fibrillation and cardiomyopathy, while novel therapies have been evaluated in clinical trials. LMNA-CM follows an aggressive yet generally stereotyped course. Early recognition of anticipated complications allows for more effective prevention and management in both symptomatic and asymptomatic patients.<br />Competing Interests: Declarations. Conflict of Interest: The authors declare no competing interests. Human and Animal Rights and Informed Consent: No animal or human subjects by the authors were used in this study.<br /> (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1534-3170
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current cardiology reports
- Publication Type :
- Academic Journal
- Accession number :
- 39869235
- Full Text :
- https://doi.org/10.1007/s11886-025-02195-x