A reagent to access methyl sulfones.

Authors :: Poplavskyi Y
Ripenko V
Bova S
Biitseva A
Dmitriv YV
Tolmachev AA
Sadkova IV
Pishel I
Grygorov O
Phan VQH
Dias HVR
Mykhailiuk PK
Source :: Nature communications [Nat Commun] 2025 Jan 29; Vol. 16 (1), pp. 1132. Date of Electronic Publication: 2025 Jan 29.
Publication Year :: 2025
Abstract: A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF <subscript>2</subscript> -, CF <subscript>3</subscript> - and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.<br />Competing Interests: Competing interests: The authors declare the following competing interests: Y. P., V. R., S. B., A. B., Y. V. D., A. A. T., I. V. S., and P. K. M. are employees of a chemical supplier Enamine. The remaining authors declare no competing interests.<br /> (© 2025. The Author(s).)