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Human iPSCs offer an alternative for modeling vascular malformation.

Authors :
DeFronzo S
Dai G
Source :
Cell stem cell [Cell Stem Cell] 2025 Feb 06; Vol. 32 (2), pp. 177-178.
Publication Year :
2025

Abstract

In this issue of Cell Stem Cell, Pan et al. generated human induced pluripotent stem cell (iPSC)-derived venous endothelial cells (iVECs) by manipulating cell-cycle dynamics and Notch signaling and demonstrated that TIE2-mutant iVECs recapitulate the pathogenesis of venous malformations. <superscript>1</superscript> Their study provides a model for further mechanistic studies and drug discovery.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2025 Elsevier Inc. All rights reserved.)

Subjects

Subjects :
Humans
Endothelial Cells metabolism
Endothelial Cells pathology
Receptors, Notch metabolism
Receptor, TIE-2 metabolism
Receptor, TIE-2 genetics
Models, Biological
Cell Differentiation
Signal Transduction
Induced Pluripotent Stem Cells metabolism
Induced Pluripotent Stem Cells cytology
Vascular Malformations pathology
Vascular Malformations metabolism

Details

Language :
English
ISSN :
1875-9777
Volume :
32
Issue :
2
Database :
MEDLINE
Journal :
Cell stem cell
Publication Type :
Academic Journal
Accession number :
39919719
Full Text :
https://doi.org/10.1016/j.stem.2025.01.008
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