Extracellular Vesicle-Based Antitumor Nanomedicines.

Authors :: Li M
Liu Y
Liu F
Chen Q
Xu L
Cheng Z
Tan Y
Liu Z
Source :: Advanced healthcare materials [Adv Healthc Mater] 2025 Feb 11, pp. e2403903. Date of Electronic Publication: 2025 Feb 11.
Publication Year :: 2025
Publisher :: Ahead of Print
Abstract: Extracellular vesicles (EVs) have emerged as promising bioactive carriers for delivering therapeutic agents, including nucleic acids, proteins, and small-molecule drugs, owing to their excellent physicochemical stability and biocompatibility. However, comprehensive reviews on the various types of EV-based nanomedicines for cancer therapy remain scarce. This review explores the potential of EVs as antitumor nanomedicines. Methods for EV extraction, drug loading, and engineering modifications are systematically examined, and the strengths and limitations of these technical approaches are critically assessed. Additionally, key strategies for developing EV-based antitumor therapies are highlighted. Finally, the opportunities and challenges associated with advancing EVs toward clinical translation are discussed. With the integration of multiple disciplines, robust EV-based therapeutic platforms are expected to be manufactured to provide more personalized and effective solutions for oncology patients.<br /> (© 2025 Wiley‐VCH GmbH.)