Helminths target macrophage epigenetics and metabolism to evade immunity.

Authors :: Everts B
Source :: Trends in parasitology [Trends Parasitol] 2025 Feb 13. Date of Electronic Publication: 2025 Feb 13.
Publication Year :: 2025
Publisher :: Ahead of Print
Abstract: Parasitic helminths are well known master regulators of host immune responses. Yet, the underlying molecular principles remain largely enigmatic. Recent work from Bohnacker et al. reveals that glutamate dehydrogenase (GDH), a metabolic enzyme secreted by Heligmosomoides polygyrus, can suppress type 2 immunity by multimodal regulation of macrophage metabolism and epigenetics.<br />Competing Interests: Declaration of interests The author declares no competing interests.<br /> (Copyright © 2025 Elsevier Ltd. All rights reserved.)