Prognosis in stage II colon cancer: Expanding the horizons of risk factors.

In the following editorial, we discuss the article by Wu et al . In this contribution, we critically review the authors' perspective and analyze the relevance of the results obtained in the original article of clinical research by Liu et al . We consider that additional factors associated with colon cancer progression have recently been described in extensive clinical research, and should be included in this analysis to achieve a more accurate prognosis. These factors include inflammation, gut microbiota composition, immune status and nutritional balance, as they influence the post-surgical survival profile of patients with stage II colorectal cancer. We also address the clinical implementation and limitations of these analyses. Evaluation of the patient´s entire context is essential for selection of the most appropriate therapy.
Competing Interests: Conflict-of-interest statement: The authors have no conflicts of interest to declare.
(©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.)