Impact of Clinicopathological Features on Gastric Cancer Stage According to TNM Classification.

Background/aim: TNM stage is crucial for patients with gastric cancer because curative resection and treatment are only possible in early TNM stages. Therefore, our objective was to assess the association of clinicopathological features with TNM stage in such patients.
Patients and Methods: The association of age, sex, tumor location and Lauren type with TNM stage was analyzed in 910 patients with gastric cancer.
Results: Age, sex, and tumor location did not have any association with TNM stage in univariate nor multivariate analyses ( p >0.05). However, compared to the diffuse and mixed types, the intestinal type (as defined by the Lauren classification) presented lower T stage of gastric cancer in the chi-squared test ( p <0.001) and this association was confirmed in the multinominal log normal model ( p =0.001).
Conclusion: The histological Lauren type of gastric cancer is associated with lower TNM T stage.
(Copyright © 2025, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)