[Effect of gamma-irradiation on malonic dialdehyde formation in the interaction of liposomes with cells].

A study was made of the effect of relatively low gamma-radiation doses (up to 10 Gy) on the ability of Ehrlich ascites tumor cells to induce peroxidation in lipids of liposomes from egg lecithin. The mechanism of this peroxidation is probably associated with the release from cells of catalyzers which perform free-radical oxidation of higher unsaturated fatty acids. Two processes occur upon irradiation of cells: disintegration of the released catalyzers, and stimulation of their release from cells. Correspondingly, the formation of malonic dialdehyde was inhibited or stimulated depending on the radiation dose and time of the combined incubation of liposomes and cells. On the basis of the data obtained a conclusion is made that the modification of the effect of malonic dialdehyde formation upon oxidation of liposomes by the exposed cells is conditioned by the effect of radiation on cell membranes.