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AA-amyloidosis in dogs: partial amino acid sequence of protein AA and immunohistochemical cross-reactivity with human and cow AA-amyloid.
- Source :
-
Comparative biochemistry and physiology. B, Comparative biochemistry [Comp Biochem Physiol B] 1985; Vol. 82 (2), pp. 211-5. - Publication Year :
- 1985
-
Abstract
- Protein AA was purified from the kidneys of dogs with spontaneous reactive amyloidosis. The protein had a blocked N-terminal. Sequence analysis of a peptide obtained after cyanogen bromide cleavage revealed an amino acid sequence corresponding to positions 24-42 of human AA. This region showed a strong homology to protein AA of other species. Antiserum to both human and dog protein AA reacted immunohistochemically with AA amyloid of human, dog and cow origin.
- Subjects :
- Amino Acid Sequence
Amyloidosis metabolism
Amyloidosis pathology
Animals
Cattle
Cattle Diseases pathology
Dog Diseases pathology
Dogs
Humans
Kidney pathology
Species Specificity
Amyloid isolation & purification
Amyloidosis veterinary
Cattle Diseases metabolism
Dog Diseases metabolism
Kidney metabolism
Serum Amyloid A Protein isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0305-0491
- Volume :
- 82
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Comparative biochemistry and physiology. B, Comparative biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 4053581
- Full Text :
- https://doi.org/10.1016/0305-0491(85)90228-7