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Histopathology of the conducting tissue of the heart in Chagas' myocarditis.
- Source :
-
American heart journal [Am Heart J] 1978 Mar; Vol. 95 (3), pp. 316-24. - Publication Year :
- 1978
-
Abstract
- The conducting tissue of the heart was studied in 25 human cases of Chagas' myocarditis with a method which employs complete serial sections mounted on continuous transparent plastic tape. The pathological changes were correlated with electrocardiographic findings. The inflammation of the acute phase of Chagas' myocarditis, as seen in one single case, did not seem to interfere with conduction through the AV system. In chronic Chagas' myocarditis the conducting tissue showed extensive and variable changes: chronic inflammation, fibrosis, atrophy and fragmentation of specific fibers, extreme dilatation and tortuosity of veins, capillaries and lymphatics, fatty infiltration, and arterial medial and intimal fibrosis. A preferential involvement of the right bundle branch and the anterior fascicles of the left branch was observed and an excellent correlation with electrocardiographic abnormalities was found. There was also evidence presented that bundle branch block may be caused by disease proximal to the bundle branches. Complete AV block seemed to be the final result of the progressive inflammatory and degenerative changes involving the conduction system in chronic Chagas' myocarditis. Inflammation and fibrosis did also involve the sinoatrial node, Purkinje fibers, intracardiac nervous ganglia, and the contractile myocardium.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Cardiomyopathies etiology
Chagas Disease complications
Chagas Disease physiopathology
Chronic Disease
Electrocardiography
Female
Heart Block etiology
Humans
Male
Middle Aged
Myocarditis etiology
Myocarditis physiopathology
Chagas Disease pathology
Heart Conduction System pathology
Myocarditis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-8703
- Volume :
- 95
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 414610
- Full Text :
- https://doi.org/10.1016/0002-8703(78)90362-9