5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline.

Authors :: Tong GL
Henry DW
Acton EM
Source :: Journal of medicinal chemistry [J Med Chem] 1979 Jan; Vol. 22 (1), pp. 36-9.
Publication Year :: 1979
Abstract: Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. This product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in Salmonella typhimurium (Ames test).

Subjects :: Animals
DNA metabolism
DNA, Neoplasm biosynthesis
Daunorubicin chemical synthesis
Daunorubicin therapeutic use
Daunorubicin toxicity
Leukemia L1210 metabolism
Mice
Mutagens
Neoplasm Transplantation
Neoplasms, Experimental drug therapy
RNA, Neoplasm biosynthesis
Rats
Daunorubicin analogs & derivatives
Heart Diseases chemically induced

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