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Stringent control of intracellular proteolysis in Escherichia coli.
- Source :
-
Journal of bacteriology [J Bacteriol] 1973 Dec; Vol. 116 (3), pp. 1253-7. - Publication Year :
- 1973
-
Abstract
- Regulation of intracellular proteolysis has been compared during amino acid deficiencies in seven double auxotrophs of Escherichia coli 9723f with a common phenylalanine requirement. Individual deficiencies were either more effective than, less effective, or equal to phenylalanine deficiency in stimulating intracellular proteolysis. For each amino acid, the same relationship prevailed in inhibiting uracil incorporation into nucleic acids, a reaction series regulated by the rel gene for stringent control. The three amino acids least abundant in the cellular protein were the least effective regulators. These findings are interpreted as supportive evidence for stringent control of intracellular proteolysis by the rel gene.
- Subjects :
- Amino Acids analysis
Autoanalysis
Carbon Dioxide biosynthesis
Carbon Radioisotopes
DNA, Bacterial biosynthesis
Escherichia coli analysis
Genes, Regulator
Leucine metabolism
Mutation
Nitrosoguanidines
Nucleic Acids biosynthesis
Phenylalanine metabolism
RNA, Bacterial biosynthesis
Stereoisomerism
Thymine metabolism
Tritium
Uracil metabolism
Amino Acids metabolism
Bacterial Proteins metabolism
Escherichia coli metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9193
- Volume :
- 116
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 4584808
- Full Text :
- https://doi.org/10.1128/jb.116.3.1253-1257.1973