Back to Search
Start Over
Mechanisms of acquired immunity and epidemiological patterns of antibody responses in malaria in man.
- Source :
-
Bulletin of the World Health Organization [Bull World Health Organ] 1974; Vol. 50 (3-4), pp. 259-66. - Publication Year :
- 1974
-
Abstract
- This paper considers the participation of macrophages, thymus-dependent lymphocytes (T-cells), and thymus-independent lymphocytes (B-cells) in man's immune response to malaria. Although phagocytosis by macrophages is an important feature of malaria the full extent of cooperation between these cells and T- and B-cells is not known. Evidence that T-cells play an important defensive role is at present unconvincing. B-cells on the other hand function importantly in the synthesis of immunoglobulins and specific antibodies and factors possibly influencing their activity are considered. Different epidemiological patterns of malaria antibodies in sera are described and the need for the routine inclusion of reliable antibody detection tests as part of malaria survey techniques, particularly where antimalarial drug usage is frequent, is emphasized.
- Subjects :
- Age Factors
Animals
Antibodies analysis
Antibody Formation
Antigen-Antibody Reactions
B-Lymphocytes immunology
Epidemiologic Methods
Female
Gambia
Humans
Immunoglobulins biosynthesis
Immunologic Techniques
Infant
Infant, Newborn
Lymphocyte Activation
Nigeria
Phagocytosis
Plasmodium falciparum immunology
Pregnancy
T-Lymphocytes immunology
Tanzania
Immunity, Active
Malaria immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0042-9686
- Volume :
- 50
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Bulletin of the World Health Organization
- Publication Type :
- Academic Journal
- Accession number :
- 4613508