Malaria and erythrocyte glucose-6-phosphate dehydrogenase variants in West Africa.

Authors :: Bienzle U
Guggenmoos-Holzmann I
Luzzatto L
Source :: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1979 Jul; Vol. 28 (4), pp. 619-21.
Publication Year :: 1979
Abstract: In a clinical study, 702 Nigerian children aged 1-6 years were examined for malaria. Comparison of morbidity rates and parasitemia of patients with different glucose-6-phosphate dehydrogenase (G6PD) status provided evidence that in heterozygous females the gene for G6PD deficiency (GdA-/GdB) confers an advantage against malaria.

Subjects :: Child
Child, Preschool
Erythrocytes enzymology
Erythrocytes parasitology
Female
Genes
Genetic Variation
Genotype
Heterozygote
Humans
Infant
Malaria enzymology
Male
Nigeria
Plasmodium
Glucosephosphate Dehydrogenase Deficiency genetics
Malaria genetics

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