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Drug-induced change in the distribution of sulfonamides in the mother rat and its fetus.
- Source :
-
Science (New York, N.Y.) [Science] 1973 Jun 01; Vol. 180 (4089), pp. 974-6. - Publication Year :
- 1973
-
Abstract
- The distribution of a highly bound antibacterial sulfonamide was markedly altered in both the mother rat and its fetus by interfering with the binding of this drug to plasma protein in the mother. This effect was due to binding displacement, since the displacing agent had little or no effect on the distribution of another sulfonamide with very low binding to plasma protein.
- Subjects :
- Animals
Binding, Competitive
Brain metabolism
Drug Interactions
Female
Fetus metabolism
Kidney metabolism
Muscles metabolism
Placenta metabolism
Pregnancy
Protein Binding
Rats
Spleen metabolism
Sulfamethoxypyridazine blood
Sulfanilamides blood
Uterus metabolism
Blood Proteins metabolism
Maternal-Fetal Exchange
Sulfamethoxypyridazine metabolism
Sulfanilamides metabolism
Sulfinpyrazone blood
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 180
- Issue :
- 4089
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 4706687
- Full Text :
- https://doi.org/10.1126/science.180.4089.974