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Microfilaruria in onchocerciasis. A clinical and epidemiological follow-up study in the Republic of Chad.
- Source :
-
Bulletin of the World Health Organization [Bull World Health Organ] 1971; Vol. 45 (3), pp. 353-69. - Publication Year :
- 1971
-
Abstract
- Microfilariae of O. volvulus were recovered from the urine of 11% of the residents of a village in the Republic of Chad where onchocerciasis was holoendemic. A follow-up study of the same population 3 years after the original investigation revealed that microfilaruria was still present and that living microfilariae of O. volvulus could be recovered from small urine samples obtained by high catherization of the ureters. Radiological changes consistent with chronic pyelitis were found in 4 out of 14 persons with microfilaruria who were examined by retrograde pyelography. The recovery of microfilariae in the urine was associated with the intensity of the infection, as determined by counts of microfilariae in skin snips and the number of onchocercomata. A systematic comparison for differences between onchocerciasis patients with and without microfilaruria revealed that the microfilaruria patients had a low weight: height ratio, deficient antibody responses in indirect haemagglutination tests with O. volvulus antigen, elevated serum aminotransferase levels, and reduced systolic blood pressure.
- Subjects :
- Adolescent
Adult
Chad
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Male
Onchocerciasis epidemiology
Skin Diseases, Parasitic epidemiology
Skin Diseases, Parasitic etiology
Urologic Diseases epidemiology
Onchocerca isolation & purification
Onchocerciasis urine
Urologic Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0042-9686
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of the World Health Organization
- Publication Type :
- Academic Journal
- Accession number :
- 5316914