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Action of bencyclane-hydrogen-fumarate on the carbohydrate metabolism of bovine lens homogenates.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1977 Jul; Vol. 27 (7), pp. 1417-20. - Publication Year :
- 1977
-
Abstract
- 1-Benzyl-1-(3-dimethylaminopropoxy)cycloheptane (bencyclane-hydrogen-fumarate; Fludilat) in a concentration of 10-2 M effects an increase in the O2 consumption and the formation of CO2 in a 10% bovine lens homogenate. This effect is even increased if the glucose-substrate supply is raised from 25 mM to 37 mM. Investigations on the concentrations at ATP, ADP and AMP show that bencyclane is able to stabilize the physiologic distribution pattern of the three free adenine nucleotides. Further, the observed changes in the distribution pattern indicated that the fumaric acid rest of bencyclane may serve as a substrate for this reaction in the same way as fumarate.
- Subjects :
- Adenosine Diphosphate metabolism
Adenosine Monophosphate metabolism
Adenosine Triphosphate metabolism
Animals
Carbon Dioxide biosynthesis
Cattle
Fumarates metabolism
In Vitro Techniques
Lens, Crystalline drug effects
Oxygen Consumption drug effects
Time Factors
Bencyclane pharmacology
Carbohydrate Metabolism
Cycloheptanes pharmacology
Lens, Crystalline metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 578465