Back to Search
Start Over
[Effect of quateron on the dopamine and DOPA content in the stomach tissues in experimental ulcer].
- Source :
-
Farmakologiia i toksikologiia [Farmakol Toksikol] 1980 Jan-Feb; Vol. 43 (1), pp. 71-4. - Publication Year :
- 1980
-
Abstract
- Experimental neurogenous ulcer is accompanied by changes in the content of dopamin (DA) and dioxypyhenylalanine (DOPA) in the tissues of different functional regions of the stomach. Two hours following injury to the pyloroduodenal region, the content of DA rises, while that of DOPA declines. After 24 hours the content of the monoamine and especially that of the amino acid decreases along with emergence and development of morphological changes (hemorrhages, erosions, ulcers) in the gastric wall. The cholinolytic quateron administered prior to the injury prevents reliably the affection of the gastric mucosa and blocks to a certain measure DOPA depletion which is recorded 24 hours following exposure to the pathogenetic agent. The utiulcerous effect of quateron is potentiated by DOPA administration (100 mg/kg).
- Subjects :
- Animals
Benzoates therapeutic use
Drug Evaluation, Preclinical
Gastric Mucosa metabolism
Rats
Stomach Ulcer metabolism
Time Factors
Dihydroxyphenylalanine metabolism
Dopamine metabolism
Ganglionic Blockers therapeutic use
Quaternary Ammonium Compounds therapeutic use
Stomach drug effects
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 0014-8318
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Farmakologiia i toksikologiia
- Publication Type :
- Academic Journal
- Accession number :
- 6103821