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Trifluoperazine antagonizes postsynaptic alpha 1-but not alpha 2-adrenoceptor-mediated pressor responses in the rat.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1984 Oct 15; Vol. 105 (3-4), pp. 343-6. - Publication Year :
- 1984
-
Abstract
- The specificity of the alpha-adrenergic blockade by trifluoperazine was tested in pithed rats. Trifluoperazine reduced the pressor effects of (-)-noradrenaline. The log dose-response curve to methoxamine, an alpha 1-agonist, was shifted to the right whereas the vasopressor responses to BHT-920, an alpha 2-agonist, were unaffected by trifluoperazine. It was concluded that trifluoperazine acts as a peripheral vascular alpha 1-antagonist in the rat.
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 105
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6150863
- Full Text :
- https://doi.org/10.1016/0014-2999(84)90629-0