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[Possibility of reversing the action of the membranotropic antibiotic, gramicidin S, on bacteria].
- Source :
-
Antibiotiki [Antibiotiki] 1980 Feb; Vol. 25 (2), pp. 121-6. - Publication Year :
- 1980
-
Abstract
- The study on the possibility of eliminating gramicidin S from the bacterial cells which had adsorbed it showed that a part of the labeled antibiotic bound by the bacteria may be washed out with buffer or salines. When the cells which had adsorbed gramicidin S were treated with lecithin emulsion, a significant part of the bound antibiotic was transferred to the lecithin liposomes. This turned the gramicidin S effect to the cells: significant but not complete reduction of the membrane barrier properties and dehydrogenase reactivation. Elimination of gramicidin S also reduced the colony forming capacity in a part of the cells.
Details
- Language :
- Russian
- ISSN :
- 0003-5637
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Antibiotiki
- Publication Type :
- Academic Journal
- Accession number :
- 6153518